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Was having trouble figuring out pyodbc http://code.google.com/p/pyodbc/ with my ODBC configuration to talk to a MS SQL or "Sequel" as some people would have it
You'll need a couple of packages installed
tdsodbc - ODBC driver for connecting to MS SQL and Sybase SQL servers
odbcinst1debian1 - Support library for accessing odbc ini files
odbcinst - Helper program for accessing odbc ini files
so just
apt-get install tdsodbc odbcinst1debian1 odbcinst